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Avatrombopag is an oral thrombopoetin agonist. In May of 2018 Avatrombopag was FDA approved for use in adults with chronic liver disease...

Mechanism of action Sickle cell disease is characterized by deoxygenated sickle hemoglobin (HbS) polymerization. The genetic mutation...

Vitamin B12 deficiency can cause extensive hematologic alterations such as pancytopenia, macrocytosis, hypersegmentation of neutrophils,...

Recommendations on Acute Bleed Management – PwHA without inhibitors No serious adverse events have been observed related to concomitant...

Previously, the 2016 guidance from the ISTH suggested not using DOACs in people with BMI >40 kg/m2 and weight >120 kg. The new...

Luspatercept For beta thalassemia [decrease blood transfusion burden ] an erythroid maturation agent, is approved for anemia in adults...

The Use of Direct Oral Anticoagulants [DOAC] in Antiphospholipid Syndrome H&O What is antiphospholipid syndrome, and what causes it?. HC ...

Rituximab is becoming the preferred second-line therapy for wAIHA, with an 80% overall response rate, a median response time of 3 to 6...

• All acute stroke patients not already on an antiplatelet agent and not receiving alteplase therapy should be given at least 160 mg of...

Backg round: Vaccines are a critical tool in the management of the COVID-19 pandemic resulting from SARS-CoV-2. Recently, AstraZeneca...

The benefits of blood donation are as follows: It orients the donor towards positive thinking. Boosts the production of red blood cells-...

Risk of VTE Recurrence The risk of recurrent VTE after stopping anticoagulants appears to be similar whether anticoagulant therapy is...

No randomized controlled trials have examined the safety and efficacy of DOAC in obese patients . Background: According to the Health...

National Comprehensive Cancer Network 2020 for patients without GI malignancies Apixaban (category 1), edoxaban after at least 5 days of...

Approximately 3% to 5% of patients with an acute PE present with hemodynamic compromise, defined as a systolic blood pressure ,90 mm Hg...

In adults with ITP for 3 months or not responded to steriod SECOND-LINE THERAPIES: SPLENECTOMY, TPO-RA, AND RITUXIMAB Recommendation In...

Hydroxyurea, indicated for managing sickle cell anemia (SCA), and L-glutamine, indicated for treating sickle cell disease (SCD), were the...

Daily therapeutic PEX has to be started as soon as possible (at least 1 but preferably 1.5 plasma volume exchanges daily), with plasma...